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SALDIVAR LAB
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2021

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Le HH, Cinaroglu SS, Manalo EC, Ors A, Gomes MM, Duan Sahbaz B, Bonic K, Origel Marmolejo CA, Quentel A, Plaut JS, Kawashima TE, Ozdemir ES, Malhotra SV, Ahiska Y, Sezerman U, Bayram Akcapinar G, Saldivar JC, Timucin E, and Fischer JM. Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells. EBioMedicine. 2021; 73:103646. Link


Mehibel M, Xu Y, Li CG, Moon EJ, Thakkar KN, Diep AN, Kim RK, Bloomstein JD, Xiao Y, Bacal J, Saldivar JC, Le QT, Cimprich KA, Rankin EB, and Giaccia AJ. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J. Clin. Invest. 2021; 131(11):e146256. Link

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Chow-Castro M, Dixon SD, and Saldivar JC. Restraining CDK1-cyclin B activation: PP2A on the cUSP(7). EMBO J. 2021; 40(11):e108486. Link

2020

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​​Eksi SE and Saldivar JC. Cohesin is out for stalled replication fork restart. Dev. Cell. 2020; 52(6):675-676. Link

2019

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Saldivar JC
 and Park D. Mechanisms shaping the mutational landscape of the FRA3B/FHIT-deficient cancer genome. Genes Chromosomes Cancer. 2019; 58(5):317-323. Link



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Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, and Spiekerkoetter E. FHIT, a novel modifier gene in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 2019; 199(1):83-98.

2018

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Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, Cortez D, Meyer T, and Cimprich KA. An intrinsic S/G2 checkpoint enforced by ATR. Science. 2018; 361(6404):806-810. Link
 



Saldivar JC 
and Cimprich KA. A new mitotic activity comes into focus. Science. 2018; 359(6371):30-31. Link
 
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Saldivar JC, Davis ML, Johnson MG, and Ricke SC. Listeria monocytogenes Adaptation and Growth at Low Temperatures: Mechanisms and Implications for Foodborne Disease. Book chapter in: Food and Feed Safety Systems and Analysis. p 227-248. 2018.

2017

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Saldivar JC, Cortez D, and Cimprich KA. The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Rev. Mol. Cell Biol. 2017; 18(10):622-36. Link
 




Hamperl S, Bocek MJ, Saldivar JC, Swigut T, and Cimprich KA. Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses. Cell. 2017; 170(4):774-86. Link

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Kiss DL, Waters CE, Ouda IM, Saldivar JC, Karras JR, Amin ZA, Mahrous S, Druck T, Bundschuh RA, Schoenberg DR, and Huebner K. Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression. Biochim. Biophys. Acta. 2017; 1860(3):374-382.

Prior to 2017

Paisie CA, Schrock MS, Karras JR, Zhang J, Miuma S, Ouda IM, Waters CE, Saldivar JC, Druck T, Huebner K. Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse. Cancer Sci. 2016; 107(4):528-35.
 
Slaats GG, Saldivar JC, Bacal, Zeman MK, Kile AC, Hynes AM, Srivastava S, Nazmutdinova J, den Ouden K, Zagers MS, Foletto V, Verhaar MC, Miles C, Sayer JA, Cimprich KA, Giles RH. DNA replication stress underlies CEP290-associated Joubert syndrome renal phenotypes. J. Clin. Invest. 2015; 125(9):3657-66. Link
 
Waters CE, Saldivar JC, Amin ZA, Schrock MS, Huebner K. FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis. Oncotarget. 2015; 6(5):3409-19. Link
 
Waters CE, Saldivar JC, Hosseini SA, Huebner K. The FHIT gene product: tumor suppressor and genome “caretaker”. Cell Mol. Life Sci. 2014; 71(23):4577-87. Link
 
Miuma S, Saldivar JC, Wang Y, Karras J, Hosseini SA, Sun J, Jin V, Huebner K. Fhit-deficiency induced global genome instability promotes mutation and clonal expansion. PLoS One. 2013; 8(11):e80730. Link
 
Hosseini SA, Horton S, Saldivar JC, Miuma S, Stampfer M, Heerema N, Huebner K. Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability. Genes Chromosomes and Cancer. 2013; 52(11):1017-29. Link
 
Saldivar JC, Bene J, Hosseini SA, Miuma S, Horton S, Heerema NA, Huebner K. Characterization of the role of Fhit in suppression of DNA damage. Adv. Biol. Regul. 2013; 53(1):77-85. Link
 
Saldivar JC, Miuma S, Bene J, Hosseini SA, Shibata H, Sun J, Wheeler LJ, Mathews CK, Huebner K. Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genetics. 2012; 8(11):e1003077. Link
 
Hu B, Nandhu MS, Sim H, Agudelo-Garcia PA, Saldivar JC, Dolan CE, Mora ME, Nuovo GJ, Cole SE, Viapiano MS. Fibulin-3 Promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res. 2012; 72(15):3873-85.
 
Milillo SR, Friedly EC, Saldivar JC, Muthaiyan A, O’Bryan C, Crandall PG, Johnson MG, Ricke SC. A review of the ecology, genomics, and stress response of Listeria innocua and Listeria monocytogenes. Crit. Rev. Food Sci. Nutr. 2012; 52(8):712-25.
 
Shibata H, Miuma S, Saldivar JC, Huebner K. Response of subtype specific human breast cancer-derived cells to PARP and Chk1 inhibition. Cancer Sci. 2011; 102(10):1882-8.
 
Huebner K, Saldivar JC, Sun J, Shibata H, Druck T. Hits, Fhits and Nits: beyond enzymatic function. Adv. Enzyme Regul. 2011; 51(1):208-217.
 
Saldivar JC, Shibata H, Huebner K. Pathology and biology associated with the fragile FHIT gene and gene product. J. Cell Biochem. 2010; 109(5):858-865.
 
Lungu B, Saldivar JC, Story R, Ricke S, Johnson MG. The combination of energy-dependent internal adaptation mechanisms and external factors enable Listeria monocytogenes to express a strong starvation survival response during multiple-nutrient starvation. Foodborne Pathog. Dis. 2010; 7(5):499-505.
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