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Our group studies how nuclear processes such as DNA replication, transcription, and repair are coordinated during the cell cycle. We integrate powerful microscopy approaches with cutting-edge sequencing technologies to uncover the elegant and dynamic biology of chromatin and how it both controls and is controlled by the cell cycle. These dynamics become disrupted in cancer and destabilize genetic and epigenetic information resulting in cell lineage instability and malignant transformation.
We are funded by generous grants from the National Institute of General Medical Sciences, the American Association for Cancer Research, the Breast Cancer Research Foundation, and the Cancer Early Detection Advanced Research Center (CEDAR). |
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We are happy you stopped by and hope you enjoy exploring who we are and what we do. Please feel free to contact us if you are interested in joining the lab!
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The Saldivar Lab is part of the Division of Oncological Sciences (www.ohsu.edu/oncological-sciences) in the Knight Cancer Institute at Oregon Health and Science University.
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